Long-Term Treatment With Interleukin-6 Receptor Inhibitor Tocilizumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease
Pioneering the future of brain science through advanced imaging and metabolic research. We decode neural energetics and glial function to revolutionize our understanding of the living brain.



Astrocytes have emerged as major players in intercellular signaling, which contribute to brain information processing, synaptic plasticity and neurovascular coupling. Astrocyte intracellular calcium signals are central to this communication and are triggered by neurotransmitter receptors in response to synaptic input.
For decades the notion that glucose is taken up and metabolized by individual brain cells according to their relative need was carved in stone. Things are much more complex. We now know that the metabolic support of the brain is a concerted effort between the vascular system, glial cells, and neurons.
Our lab has spearheaded the use of reconstructions of realistic cortical vascular networks to investigate the neurovascular unit. We published work on the vascular topology, oxygen transport and fluid dynamics at the single erythrocyte level. This work has been carried out in a long-standing collaboration with colleagues at the Institute for Fluid Dynamics at the ETH Zurich.
For decades the notion that glucose is taken up and metabolized by individual brain cells according to their relative need was carved in stone. Things are much more complex. We now know that the metabolic support of the brain is a concerted effort between the vascular system, glial cells, and neurons.
We are working on breakthroughs in our current understanding of normal brain function and how we can target diseases of the central nervous system with novel approaches. We teach modern pharmacology to medical and science students.
About us
Our team studies brain energy metabolism and glial biology with the tools of tomorrow. Join us on this exciting journey.
Meet the Team 25